Journal Article Epublish
PubMed: 40595151 DOI: 10.1038/s41598-025-07316-8
Family history of non-communicable diseases and the risk of cardiovascular-kidney-metabolic syndrome.
Sci Rep 15(1):20710
Authors: Hyeseung Lee, Jinyoung Jeong, Yesol Yim, Lee Smith, Damiano Pizzol, Jiyoung Hwang, Dong Keon Yon
Affiliations
- Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.
- Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea. Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
- Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK. Department of Public Health, Faculty of Medicine, Biruni University, Istanbul, Turkey.
- Health Unit, Eni, San Donato Milanese, Italy.
- Health Unit, Eni, Maputo, Mozambique.
- Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.
- Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea. Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. Department of Pediatrics, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.
Abstract
Cardiovascular-kidney-metabolic (CKM)-related diseases are known to be influenced by family history; however, few studies have analyzed associations between them. Thus, this study aims to analyze associations between family history of non-communicable diseases with CKM-related diseases and CKM stages. This study utilized data from the Korea National Health and Nutrition Examination Survey to calculate the weighted prevalence and 95% confidence intervals (CI) of CKM syndrome and CKM-related diseases based on family history of non-communicable diseases including hypertension, diabetes, hyperlipidemia, ischemic heart disease, and stroke. Adjusted odds ratios() with 95% CI were calculated using multivariable logistic regression and partial proportional odds models. CKM syndrome was classified according to the criteria established by the American Heart Association (early-advanced stage, 0-4). This study analyzed family history, prevalence rates of CKM-related diseases, and CKM syndrome stages in 57,340 participants. The results indicated higher prevalence rates for individuals with a family history of CKM-related diseases. Furthermore, individuals with such a history were at greater risk of being classified into more advanced stages of CKM syndrome compared to those without. In particular, when focusing on the most advanced stage (stage ≥ 4) of CKM syndrome, a family history of hypertension increased the risk by 43% (95% CI, 32-54), diabetes by 54% (41-67), hyperlipidemia by 97% (41-67), ischemic heart disease by 147% (123-173), and stroke by 106% (90-124). The family history of CKM-related diseases may increase the prevalence of these diseases and influence CKM syndrome progression stages. These findings suggest implementing early diagnosis and management programs that take family history into account.
MeSH
Diabetes Mellitus, Myocardial Ischemia, Hypertension, Hyperlipidemias, Heart Diseases, Stroke, Heart, Kidney, Noncommunicable Diseases, Prevalence, History, Communicable Diseases, Metabolic Syndrome