Journal Article Review Epublish
PubMed: 40598533 DOI: 10.1186/s12964-025-02317-6
Progress on multifunctional transmembrane protein ATG9A.
Cell Commun Signal 23(1):314
Authors: Xi Lin, Lin Liang, Shan Liao, Yanling Li, Yanhong Zhou
Affiliations
- Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Central South University, Changsha, 410013, China.
- Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, 410011, Hunan, China.
- Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
- Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Central South University, Changsha, 410013, China.
- Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, 410011, Hunan, China.
Abstract
ATG9A is the only transmembrane protein among the components required for autophagosome formation and participates in multiple cellular biological processes. ATG9A undergoes intracellular transport via microtubules and actin. As a lipid scramblase, ATG9A facilitates the random movement of lipid molecules between the inner and outer leaflets of lipid bilayers. Additionally, it can influence the homeostasis of the plasma membrane and membranous organelles. In autophagy, ATG9A is recruited to autophagic initiation sites to initiate cellular autophagy and subsequently participates in the process by promoting lipid transfer. Moreover, ATG9A also plays roles in maintaining neuronal homeostasis and is involved in embryonic development, infection, and immune responses. In this review, we comprehensively and systematically summarize the roles and mechanisms of ATG9A, aiming to provide a new perspective for understanding its functions.
MeSH
Autophagy, Homeostasis, Cell Communication, Membranes