Journal Article Review Epublish 1 citation
PubMed: 40603504 DOI: 10.1038/s44324-024-00038-x
Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases.
npj metabolic health and disease.. 2(1):36
Authors: Helena Borland Madsen, Jon Ambæk Durhuus, Ove Andersen, Per Thor Straten, Anne Rahbech, Claus Desler
Affiliations
- Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
- Department of Clinical Research, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, 2650, Copenhagen, Denmark.
- National Center for Cancer Immune Therapy, Department of Oncology, University Hospital Herlev, Copenhagen, Denmark.
- Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.
MeSH
Mitochondria, Noncommunicable Diseases, Covid-19, Communicable Diseases