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Publications

Journal Article Epublish 4 citations

PubMed: 40604257 DOI: 10.1038/s44303-025-00084-0

Spillover can limit accurate signal quantification in MPI.

Npj Imaging 3(1):20

Authors: Ali Shakeri-Zadeh, Shreyas Kuddannaya, Adnan Bibic, Jeff W M Bulte

Affiliations

  • The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Inc. Baltimore, MD, USA.
  • The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Inc. Baltimore, MD, USA.
  • Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Department of Chemical & Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA.
  • Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.

Abstract

Accurate quantification of the magnetic particle imaging (MPI) signal in vivo remains a significant technical challenge. We assessed the "spillover effect", defined as leakage of signal from adjacent areas within a region of interest, within a field of view containing multiple hot spots, a scenario frequently encountered in vivo after systemic administration of a magnetic tracer. Using custom-designed phantom and in vivo mouse studies we determined the impact of fiducial positioning, iron content, and the iron concentration ratios within those hot spots, as well as the suitability of four different MPI scan modes for accurate signal quantification. Adjustment of the specific "target-to-fiducial distance (TFD)" and "target-to-fiducial Fe concentration ratios (TFCR)" significantly reduced the spillover effect. It's implementation to mitigate spillover effects will increase the accuracy of MPI for in vivo magnetic tracer quantification.