Journal Article Review Epublish
PubMed: 40607029 DOI: 10.3389/fnut.2025.1583889
Precision nutrition management in hyperlipidemia-associated acute pancreatitis: mechanistic insights and personalized therapeutic approaches.
Front Nutr 12:1583889
Authors: Jingyuan Ma, Xing Wan, Jifeng Liu, Xuyang Hu, Yanna Ma, Yunhai Gao
Affiliations
- The First Clinical Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
- The First Affiliated Hospital of Dalian Medical University, Dalian, China. Institute of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Dalian, China.
- The First Affiliated Hospital of Dalian Medical University, Dalian, China.
- The Second Clinical Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Abstract
Hyperlipidemia-associated acute pancreatitis (HLAP), an acute inflammatory disorder triggered by dyslipidemia, has witnessed a rising global incidence with significant health implications. The pathogenesis of HLAP involves complex interactions among lipid metabolism dysregulation, inflammatory cascades, and oxidative stress. Conventional therapeutic approaches, while providing partial symptomatic relief, exhibit limitations in addressing individual variability. Precision nutrition management emerges as a novel paradigm integrating multi-omics profiling (genomic, metabolomic) and clinical parameters to develop personalized intervention strategies. This comprehensive review analyzes the pathophysiological mechanisms linking lipid dyshomeostasis to HLAP progression, systematically evaluates the scientific foundation for precision nutrition interventions, and identifies key gaps in current implementation strategies. Furthermore, we examine current research limitations and outline future avenues for enhancing therapeutic efficacy via personalized nutritional interventions.
MeSH
Hyperlipidemias, Pancreatitis, Precision Medicine, Therapeutics