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Journal Article Epublish 4 citations

PubMed: 40611225 DOI: 10.1186/s12894-025-01844-1

The relationship between the triglyceride glucose-waist height ratio and benign prostatic hyperplasia in middle-aged and elderly adults: a nationwide cohort study.

BMC Urol 25(1):153

Authors: Bing Li, Zhiqiang Zhang, Junping Li, Xiaoqiang Liu

Affiliations

  • Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
  • Graduate School of Tianjin Medical University, Tianjin Medical University, Tianjin, 300070, China.
  • Department of Oncology, Zibo city municipal hospital, Zibo, China.
  • Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

Abstract

OBJECTIVE

Currently, evidence regarding the relationship between variations in the Triglyceride Glucose-Waist-to-Height Ratio (TyG-WHtR) and benign prostatic hyperplasia (BPH) remains scarce. This study aimed to examine the potential association between alterations in TyG-WHtR and the risk of developing BPH.

METHODS

This study enrolled 3,296 male participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS). Multivariable logistic regression analysis combined with restricted cubic spline models was employed to explore the potential relationship between TyG-WHtR variation and the risk of developing BPH.

RESULTS

Over a 4-year follow-up period, 267 individuals were diagnosed with BPH. Elevated TyG-WHtR values were significantly associated with a higher risk of BPH (OR = 1.20, 95% CI: 1.02-1.43, p = 0.031), demonstrating a clear dose-response trend (p = 0.01). Furthermore, subgroup analyses revealed that this positive correlation between TyG-WHtR and BPH risk was consistently observed across multiple stratifications.

CONCLUSION

These findings highlight the potential metabolic links between TyG-WHtR and BPH, and underscore the need for future longitudinal studies to explore whether targeting these pathways may aid in BPH prevention.

MeSH

Longitudinal Studies, Cohort Studies, Urologic Diseases, Waist-Height Ratio, Aged, Prostatic Hyperplasia, Hyperplasia, Triglycerides