Journal Article Review Epublish 1 citation
PubMed: 40612188 DOI: 10.1177/30502225251304582
The Global Burden of Major Gastrointestinal Anomalies: A Global, Systematic Review of Gastrointestinal Anomaly Birth Prevalence.
Sage Open Pediatr 12:30502225251304582
Authors: Kelsey R Landrum, Pamela Espinoza, Cesia Cotache-Condor, Brian W Pence, Henry E Rice, Mark G Shrime, Chris B Agala, Emily R Smith, Jessie K Edwards
Affiliations
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- Duke Global Health Institute, Durham, NC, USA.
- Center for Global Surgery and Health Equity, Duke University, Durham, NC, USA.
- Bloomberg School of Public Health, Johns Hopkins University, MD, USA.
- Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
- Mercy Ships, Lindale, TX, USA.
- Harvard University Medical School, Harvard Program in Global Surgery and Social Change, Boston, MA, USA.
- Department of Emergency Medicine, Duke University School of Medicine, Durham, NC, USA.
- Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abstract
The burden of congenital gastrointestinal (GI) anomalies is poorly understood. The aim of this systematic review to assess the global prevalence of congenital gastrointestinal (GI) anomalies. We conducted a systematic review of global population-level birth prevalence of gastroschisis, omphalocele, intestinal atresia, esophageal atresia, congenital diaphragmatic hernia, Hirschsprung's disease, and anorectal malformation. We identified 103 studies from high and middle-income countries. Gastroschisis was the most reported condition. Studies reported geographic heterogeneity in gastroschisis, omphalocele, esophageal atresia, Hirschsprung's disease, congenital diaphragmatic hernia, and anorectal malformation prevalence. The prevalence of gastroschisis, omphalocele, and Hirschsprung's disease prevalence was reported to have increased over recent decades. Mean prevalence per 10 000 live and total births ranged from 2.1 to 4.4 cases and 1.4 to 3.6 per 10 000 live or total births, respectively. There is limited surveillance for congenital GI anomalies in LICs and potential temporal and geographic trends that need to be further investigated.
MeSH
Hernia, Parturition, Hernias, Diaphragmatic, Congenital, Gastroschisis, Esophageal Atresia, Prevalence, Anorectal Malformations, Hernia, Diaphragmatic, Omphalocele