Journal Article Review Epublish
PubMed: 40624030 DOI: 10.1038/s41540-025-00556-4
Data-driven synthetic microbes for sustainable future.
NPJ Syst Biol Appl 11(1):74
Authors: Iqra Mariam, Ulrika Rova, Paul Christakopoulos, Leonidas Matsakas, Alok Patel
Affiliations
- Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resources Engineering, Luleå University of Technology, SE-971 87, Luleå, Sweden.
- Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resources Engineering, Luleå University of Technology, SE-971 87, Luleå, Sweden.
Abstract
The escalating global environmental crisis demands transformative biotechnological solutions that are both sustainable and scalable. This perspective advocates Data-Driven Synthetic Microbes (DDSM); engineered microorganisms designed through integrating omics, machine learning, and systems biology to tackle challenges like PFAS degradation, greenhouse gas mitigation, and sustainable biomanufacturing. DDSMs offer a rational framework for developing robust microbial systems, reshaping the future of synthetic biology toward environmental resilience and circular bioeconomy.
MeSH
Systems Biology