Journal Article Review Ppublish
PubMed: 40637400 DOI: 10.1152/ajpheart.00139.2025
Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy.
Am J Physiol Heart Circ Physiol 329(2):H572-H591
Authors: Alice E Zemljic-Harpf, Jacqueline A Bonds, Juan Pablo Zuniga-Hertz, Hemal H Patel
Affiliations
- Veterans Affairs San Diego Healthcare System, San Diego, California, United States.
- Department of Anesthesiology, University of California, San Diego, California, United States.
- Department of Neuroscience, Cognition & Behavior, University of San Diego, San Diego, California, United States.
Abstract
Diabetic cardiomyopathy (DCM) is a cardiac disorder characterized by structural and functional impairments independent of coronary artery disease. Membrane microdomains, including lipid rafts and caveolae, play a crucial role in cardiac signaling, insulin receptor trafficking, and ion channel regulation. In diabetes, disrupting these microdomains leads to impaired insulin signaling, oxidative stress, and mitochondrial dysfunction, exacerbating cardiac pathology. This review explores the role of caveolins and lipid rafts in DCM and how their dysfunction contributes to disease progression. We highlight how therapeutics used to manage patients with diabetes may impact microdomain integrity. Future research should focus on targeting membrane microdomains for novel treatments.
MeSH
Membrane Microdomains, Insulin, Diabetic Cardiomyopathies, Therapeutics, Caveolae, Membranes, Cardiomyopathies