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Publications

Journal Article Review Epublish

PubMed: 40647273 DOI: 10.3390/nu17132167

The Role of Vitamin D in Inflammatory Bowel Diseases: From Deficiency to Targeted Therapeutics and Precise Nutrition Strategies.

Nutrients 17(13)

Authors: Giuseppe Dell'Anna, Fabrizio Fanizzi, Alessandra Zilli, Federica Furfaro, Virginia Solitano, Tommaso Lorenzo Parigi, Ambra Ciliberto, Jacopo Fanizza, Francesco Vito Mandarino, Lorenzo Fuccio, Antonio Facciorusso, Gianfranco Donatelli, Mariangela Allocca, Sara Massironi, Vito Annese, Laurent Peyrin-Biroulet, Silvio Danese, Ferdinando D'Amico

Affiliations

  • Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy.
  • Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, 20097 San Donato Milanese, Italy.
  • Unité d'Endoscopie Interventionnelle, Hôpital Privé des Peupliers, 75013 Paris, France.
  • Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina 56, 20132 Milan, Italy.
  • Gastroenterology Unit, Istituti Ospedalieri Bergamaschi, 24046 Zingonia (Bergamo), Italy.
  • Gastroenterology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Gastroenterology Unit, Faculty of Medicine and Surgery, University of Salento, 73100 Lecce, Italy.
  • Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy.
  • INSERM NGERE, Department of Gastroenterology, INFINY Institute, CHRU Nancy, 54500 VandÅ“uvre-lès-Nancy, France.

Abstract

BACKGROUND

Vitamin D plays a crucial role in immune modulation, gut barrier integrity, and inflammation regulation, making it highly relevant in inflammatory bowel disease (IBD). IBD patients often exhibit vitamin D deficiency, which has been linked to increased disease activity, impaired mucosal healing, and a higher risk of complications, including infections and osteoporosis.

METHODS

This review examines the biological functions of vitamin D in maintaining intestinal homeostasis, particularly in the context of IBD. It discusses the prevalence and consequences of vitamin D deficiency in IBD, including its potential to exacerbate disease progression, impair treatment efficacy, and negatively impact long-term health outcomes. Furthermore, therapeutic strategies to address vitamin D deficiency are explored, including supplementation approaches, dosing strategies, and precision nutrition interventions that aim to personalize vitamin D management based on individual patient needs and disease characteristics.

RESULTS

By synthesizing the latest evidence, this review highlights the critical role of vitamin D in IBD management, underlining how optimal vitamin D levels may not only improve disease control but also enhance patient quality of life and reduce the risk of long-term complications associated with the disease.

CONCLUSIONS

Understanding the importance of vitamin D in IBD could help refine treatment strategies and promote better health outcomes for affected individuals.

MeSH

Vitamin D, Vitamins, Diet, Food, Inflammatory Bowel Diseases, Precision Medicine, Therapeutics, Colitis, Ulcerative