Journal Article Review Epublish
PubMed: 40647577 DOI: 10.3390/diagnostics15131578
Comparison of Dynamic Susceptibility Contrast and Arterial Spin Labeling MRI Perfusion in the Assessment of Stroke and Steno-Occlusive Disease: A Systematic Review and Meta-Analysis.
Diagnostics (Basel) 15(13)
Authors: Agnieszka Sabisz, Beata Brzeska, Edyta Szurowska, Arkadiusz Szarmach
Affiliations
- 2nd Department of Radiology, Medical University of Gdansk, Mariana Smoluchowskiego 17, 80-210 Gdansk, Poland.
Abstract
Background/Objectives: Assessment of the hemodynamic status of the brain in patients with cerebrovascular diseases is crucial for providing valuable clinical information. Various magnetic resonance perfusion sequences are used in studies, and one of the current challenges is comparing methods utilizing exogenous and endogenous contrast. This meta-analysis aimed to evaluate the correlation between arterial spin labeling (ASL)-derived perfusion parameters and those obtained by dynamic susceptibility contrast (DSC) perfusion in stroke and steno-occlusive diseases. Methods: A systematic review and meta-analysis were conducted, including 14 studies that reported correlation coefficients between perfusion MRI sequences in the assessment of stroke or steno-occlusive diseases. The correlation between ASL-derived cerebral blood flow (ASL-CBF) and DSC-derived cerebral blood flow (DSC-CBF) was analyzed, considering different magnetic field strengths (1.5 T and 3.0 T), sequence types, and brain regions. Additionally, real and normalized data were compared. Results: A moderate positive correlation was found between ASL-CBF and DSC-CBF (R = 0.464). Subgroup analysis demonstrated that ASL-CBF and DSC-CBF correlated at 3.0 T (R = 0.401) and 1.5 T (R = 0.700). No significant differences were observed in correlation coefficients based on sequence type or brain region. Normalized data demonstrated a higher correlation coefficient compared to real data (Rreal = 0.393, Rnorm = 0.496). Additionally, the correlation coefficient between ASL-CBF and DSC-derived mean transit time (DSC-MTT) for all included studies was R = -0.422. Conclusions: ASL-derived perfusion parameters demonstrate moderate-to-high agreement with DSC perfusion parameters in stroke and steno-occlusive patients. These findings support the potential utility of ASL as a non-invasive alternative to DSC perfusion imaging in clinical and research settings.
MeSH
Blood, Stroke, Brain, Blood Circulation, Perfusion Imaging