Journal Article Epublish
PubMed: 40649245 DOI: 10.3390/molecules30132729
Heterojunction-Engineered g-C 3N 4/TiO 2 Nanocomposites with Superior Bilirubin Removal Efficiency for Enhanced Hemoperfusion Therapy.
Molecules 30(13)
Authors: Lingdong Meng, Shouxuan Tao, Liyao Wang, Yu Cao, Jianhua Hou, Chengyin Wang
Affiliations
- Hemodialysis Center of Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou 225000, China.
- College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225000, China.
- Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
- College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225000, China.
Abstract
The g-C 3N 4/TiO 2 intercalation composite material was successfully synthesized and used as the adsorbent in the hemoperfusion device. Then, the cytotoxicity and hemolysis rate were studied. The experimental results proved that g-C 3N 4/TiO 2 was non-toxic to cells and would not cause hemolysis. The adsorption and removal performance of the composite material for bilirubin (BR) was explored as well. The maximum adsorption capacity for BR was 850 mg·g -1. Compared with the chemical hemoperfusion adsorbent coconut shell activated carbon (AC), the g-C 3N 4/TiO 2 material presented excellent adsorption performance. Furthermore, SEM, infrared spectroscopy, XPS and other characterizations results indicated that g-C 3N 4/TiO 2 has an effective adsorption effect on bilirubin, and the main adsorption mechanism is chemical adsorption. This study demonstrates that g-C 3N 4/TiO 2 may be a potential adsorbent for hemoperfusion in the treatment of hyperbilirubinemia.
MeSH
Hemoperfusion, Hemolysis, Therapeutics, Nanocomposites, Bilirubin