Journal Article Review Epublish 3 citations
PubMed: 40649346 DOI: 10.3390/molecules30132832
Crithmum maritimum L.: Phytochemical Profile, Biological Activities, and Therapeutic Potential.
Molecules 30(13)
Authors: Velina Dzhoglova, Stanislava Ivanova, Michaela Shishmanova-Doseva, Kremena Saracheva
Affiliations
- Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
- Research Institute, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
- Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Abstract
Members of the Apiaceae family have been recognized since antiquity for their health-promoting properties. The halophytic species Crithmum maritimum L. (commonly known as sea fennel) has been used in traditional medicine since antiquity, largely due to its diverse and bioactive phytochemical composition. The plant's complex chemical composition includes terpenoids, phenolic acids, flavonoids, tannins, dietary fibers, fatty acids, and essential vitamins. Essential oils (EOs) extracted from C. maritimum L. have demonstrated a wide range of biological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, and anticancer effects. Moreover, recent evidence suggests additional biofunctional roles such as cognitive enhancement and the inhibition of melanin synthesis in the skin. Extracts of the plant exhibit significant bioactivity, having shown antiparasitic, hypoglycemic, vasodilatory, and probiotic effects in preliminary studies. Despite this pharmacological potential, the number of experimental studies (particularly in vivo investigations) remains limited. The present review consolidates existing in vitro and in vivo research on C. maritimum L. with an analysis of 79 scientific studies aimed at elucidating its therapeutic potential and identifying future research directions necessary to support its broader application in biomedical and functional food contexts.
MeSH
Oils, Volatile, Research, Therapeutics, Phytochemicals