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Publications

Journal Article Review Epublish

PubMed: 40649910 DOI: 10.3390/ijms26136134

Plasma and Serum LC-MS Lipidomic Fingerprints of Bipolar Disorder and Schizophrenia.

Int J Mol Sci 26(13)

Authors: Marija Takić, Vesna Jovanović, Suzana Marković, Zoran Miladinović, Milka Jadranin, Gordana Krstić, Čedo Miljević, Vele Tešević, Boris Mandić

Affiliations

  • Group for Nutrition and Metabolism, Center of Research Excellence for Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Subotića 4, 11000 Belgrade, Serbia.
  • University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
  • University of Belgrade-Faculty of Medicine, Institute of Forensic Medicine, Deligradska 31a, 11000 Belgrade, Serbia.
  • Institute of General and Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.
  • Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia.
  • University of Belgrade-Faculty of Medicine, dr Subotića 8, 11000 Belgrade, Serbia.

Abstract

Bipolar disorder (BD) and schizophrenia (SCH) are results of the complex interactions between genetic and environmental factors, and the underlying pathophysiology is not yet completely understood. The current diagnostic criteria for psychiatric diagnosis are based purely on clinical phenomenology and they are limited to psychiatrist judgment after a standardized clinical interview, with no precise biomarkers used to discriminate between the disorders. Besides gaps in the understanding and diagnosis of these diseases, there is also a need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. To fulfill existing gaps, the establishment of disorder biomarker sets is a necessary step. LC-MS lipidomic blood sample analysis is one of the ongoing omics approaches. In the last ten years, several studies have identified alterations in lipid metabolism associated with BD and SCH, and this review summarizes current knowledge on their lipidomic patterns, which is essential for identifying lipid biomarkers. Currently, findings indicate decreases in plasmalogens and acyl-carnitines, along with increases in certain triacylglycerol species, shared by both conditions. In contrast, serum LC-MS lipidomic profiles of sphingolipids including ceramides could be unique to BD, indicating the need for further investigation in future studies.

MeSH

Sphingolipids, Bipolar Disorder, Serum, Biomarkers, Schizophrenia, Ceramides, Diagnosis, Therapeutics, Lipidomics, Plasma, Phospholipids