Journal Article Review Epublish 9 citations
PubMed: 40650268 DOI: 10.3390/ijms26136483
Autism Spectrum Disorder as a Multifactorial Disorder: The Interplay of Genetic Factors and Inflammation.
Int J Mol Sci 26(13)
Authors: George Ayoub
Affiliations
- Psychology, Santa Barbara City College, Santa Barbara, CA 93109, USA.
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by difficulty with social communication, behavior, and sensory integration. With its prevalence rising worldwide in recent decades, understanding and mitigating the origins of ASD has become a priority. Though its etiology is multifactorial, the current research highlights two major contributors, genetic susceptibilities and environmental inflammatory exposures, leading to oxidative stress during critical developmental periods. We explore how genetic variations, including those affecting cerebral folate metabolism, and various inflammatory triggers, including exposure to inflammatory agents during both the fetal and post-fetal period, intersect to influence the development of ASD, giving rise to specific symptoms seen in autism.
MeSH
Leucovorin, Autism Spectrum Disorder, Oxidative Stress, Autistic Disorder