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Publications

Journal Article Review Ppublish

PubMed: 40656613 DOI: 10.3748/wjg.v31.i25.107260

Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets.

World J Gastroenterol 31(25):107260

Authors: Nevena M Gajovic, Ivan P Jovanovic, Miodrag V Jocic, Bojan Stojanovic, Irfan F Corovic, Nevena Todorovic, Bojana J Simovic Markovic, Amedeo Amedei

Affiliations

  • Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Institute for Transfusiology and Haemobiology, Military Medical Academy, Belgrade 11000, Serbia.
  • Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Department of Internal Medicine, General Hospital of Novi Pazar, Novi Pazar 36300, Serbia.
  • Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy.
  • Clinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, Belgrade 11000, Serbia.
  • Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
  • Network of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Florence 50139, Italy.

Abstract

Liver cancer remains one of the leading causes of cancer-related mortality worldwide, with hepatocellular carcinoma representing its most prevalent form. This review provides a comprehensive summary of the key factors driving the initiation and progression of hepatocellular carcinoma, with a particular emphasis on immune-related mechanisms. Furthermore, we delve into the emerging roles of galectins, particularly galectin-1 and galectin-3, in hepatocellular carcinoma pathobiology, underscoring their potential utility as biomarkers for assessing disease severity and progression. These insights contribute to a better understanding of the molecular and immunological underpinnings of hepatocellular carcinoma, paving the way for more targeted therapeutic strategies.

MeSH

Carcinoma, Hepatocellular, Galectins, Neoplasms, Liver, Liver Neoplasms, Gastrointestinal Diseases