Journal Article Review Epublish
PubMed: 40661149 DOI: 10.3389/fcell.2025.1622544
Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention.
Front Cell Dev Biol 13:1622544
Authors: Shaokai Tang, Jianhua Zhang, Jiawei Chen, Zeng Zhou, Qinqin Lin
Affiliations
- College of Sports Science, Jishou University, Jishou, China.
- School of Physical Education and Art, Hunan University of Medicine, Huaihua, China.
- Hunan Mechanical and Electrical Polytechnic, Student Affairs Office, Changsha, China.
- Department of Physical Education, Central South University, Changsha, China.
- School of Physical Education, Yanshan University, Qinhuangdao, China.
Abstract
Neurodegenerative diseases represent a major global cause of mortality and disability. These disorders are characterized by complex pathogenesis and currently lack effective therapeutic strategies. Iron, a vital trace element for normal brain function, has been implicated in the pathogenesis of neurodegenerative diseases via the ferroptosis pathway. Emerging evidence indicates that exercise can suppress ferroptosis directly or indirectly by regulating iron metabolism, oxidative stress, and exerkine expression, thereby conferring neuroprotection. This review summarizes current insights into the role of ferroptosis in neurodegenerative diseases and explores the mechanisms by which exercise modulates the ferroptosis pathway, offering a scientific rationale for exercise-based interventions in brain health.
MeSH
Exercise, Brain, Ferroptosis, Neurodegenerative Diseases