Journal Article Review Epublish
PubMed: 40687837 DOI: 10.1016/j.isci.2025.112901
Ferroptosis: A critical link to treatment resistance in esophageal carcinoma.
iScience 28(7):112901
Authors: Ming-Xin Tang, Jin-Feng Chen, Fa-Zhi Zhao, Jun Peng
Affiliations
- Department of Gastroenterology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Department of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
- Department of Gastric Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
- Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Abstract
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxide accumulation, induces lethal oxidative damage and disrupts cell membrane integrity. Its role in malignant tumors, such as esophageal carcinoma (EC), is increasingly recognized, offering a promising therapeutic avenue to overcome treatment resistance. Emerging evidence highlights the involvement of genes, proteins, the metabolism of metal ions, and tumor microenvironmental factors in modulating ferroptosis-associated resistance mechanisms in EC. This review systematically outlines current insights into ferroptosis in EC resistance and explores novel therapeutic strategies, including ferroptosis-targeted agents, nanotechnology, natural compounds, and multimodal approaches. Nevertheless, overcoming EC resistance remains a significant clinical challenge, warranting further investigation.
MeSH
Cells, Neoplasms, Ferroptosis, Therapeutics