Journal Article Epublish
PubMed: 40699654 DOI: 10.3390/cimb47040255
The Effect of Kidney Transplantation and Immunosuppressive Therapy on Adipose Tissue Content and Adipocytokine Plasma Concentration-Preliminary Study.
Curr Issues Mol Biol 47(4)
Authors: Daria Śleboda-Taront, Joanna Stępniewska, Barbara Dołęgowska, Emilia Marchelek, Katarzyna Dołęgowska, Małgorzata Marchelek-Myśliwiec
Affiliations
- Department of Laboratory Diagnostics, University Clinical Hospital No. 2, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
- Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
- Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
- American University of the Caribbean School of Medicine, Sizer St. Preston PR1 1JQ, UK.
Abstract
Kidney transplantation is the preferred treatment for chronic kidney disease, significantly improving patient survival and quality of life. After the procedure, there is a gradual tendency to normalize most of the physiological and metabolic processes, but the need for immunosuppression may lead to new disorders related to the drugs' side effects and changes in proportions of body composition. The aim of the study was to analyze the concentrations of adipocytokines such as leptin, adiponectin, visfatin, and resistin, and to assess the body composition in patients with stabilized kidney graft function treated with tacrolimus, mycophenolate mofetil, and glucocorticosteroids. A total of 47 participants were enrolled, including 25 kidney transplant recipients on uniform immunosuppressive therapy and 22 healthy controls. The concentrations of leptin, adiponectin, and IL-6 in kidney transplant recipients was significantly higher than in the control group (p = 0.014, p = 0.031, p = 0.000, respectively), while the other adipocytokines, such as visfatin and resistin, do not obtain statistically significant differences. The bioelectrical impedance analysis showed statistically significant differences for fat-free mass index (p = 0.027), visceral fat area (p = 0.023), waist circumference (p = 0.006), fat mass (p = 0.028), and fat mass index (p = 0.034), all of which had higher mean values in the study group. Preliminary findings suggest that kidney transplantation leads to significant alterations in adipocytokines levels, with potential implications for metabolic health.
MeSH
Nicotinamide Phosphoribosyltransferase, Leptin, Resistin, Adiponectin, Body Composition, Kidney, Transplants, Therapeutics, Kidney Transplantation, Tissues, Adipokines, Immunosuppression Therapy, Transplantation, Adipose Tissue, Plasma