Journal Article Epublish 1 citation
PubMed: 40708780 DOI: 10.1002/fsn3.70515
Examining the Relationship Between Dietary Glycemic Load (GL), Glycemic Index (GI), and the Odds of Diminished Ovarian Reserve: A Case-Control Study.
Food Sci Nutr 13(7):e70515
Authors: Abed Ghavami, Mahdieh Khodarahmi, Sanaz Mehrabani, Amin Mokari-Yamchi, Hatav Ghasemi-Tehrani, Mahdi Vajdi, Gholamreza Askari
Affiliations
- Department of Clinical Nutrition, School of Nutrition and Food Sciences Isfahan University of Medical Sciences Isfahan Iran.
- Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran.
- Maternal and Childhood Obesity Research Center Urmia University of Medical Sciences Urmia Iran.
- Department of Obstetrics and Gynecology, School of Medicine Isfahan University of Medical Sciences Isfahan Iran.
- Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran.
Abstract
A decline in both the number and quality of oocytes within the ovaries indicates a reduced ovarian reserve. As lifestyle factors, particularly dietary habits, can influence ovarian reserve, this study aimed to assess the relationship between dietary glycemic load (GL) and glycemic index (GI) and odds of diminished ovarian reserve (DOR). The current case-control study includes 370 women, consisting of 120 women who had DOR and 250 control participants. The two groups were matched based on age and body mass index (BMI). The dietary information was collected using a semiquantitative food frequency questionnaire (FFQ) that consisted of 80 items. A multivariable logistic regression approach was used to assess the association of dietary GI and GL scores with the odds of DOR, adjusting for potential confounders. The initial result revealed that there was no significant association between the odds of DOR and the dietary GI and GL when assessed through both crude and adjusted analyses, which accounted for factors such as physical activity and energy intake. However, when adjustments were made for factors such as physical activity, energy intake, fat mass (FM), and BMI, it was observed that women who were in the highest quartile of the dietary GL and GI scores had a 13% (OR 1.13; 95% CI 1.07-2.68, p = 0.042) and 19% (OR 1.19; 95% CI 0.59-1.87, p = 0.038) higher odds of DOR, respectively. Higher dietary GL and GI may be associated with increased odds of DOR. However, it is essential to conduct further studies with prospective design to establish this relationship and explore potential underlying mechanisms.
MeSH
Exercise, Case-Control Studies, Ovary, Ovarian Reserve, Energy Intake, Glycemic Index, Glycemic Load