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Publications

Journal Article Review Epublish 5 citations

PubMed: 40718547 DOI: 10.1093/ofid/ofaf396

Systematic Review and Expert Consensus on the Use of Long-acting Monoclonal Antibodies for Prevention of Respiratory Syncytial Virus Disease: ARMADA (Advancing RSV Management And Disease Awareness) Taskforce.

Open Forum Infect Dis 12(7):ofaf396

Authors: Paolo Manzoni, Eugenio Baraldi, Fabio Midulla, Olivier Claris, Sandro Dessardo, Terho Heikkinen, Richard Thwaites, Bosco Paes, Xavier Carbonell-Estrany, Dmytro Dobryanskyy, Merih Cetinkaya, Adel S Al Harbi, Ji-Man Kang, Anne Goh Eng Neo, Hsin Chi, Guilherme Sant'Anna, Mónica Villa Guillén, Gonzalo Luis Mariani, Marco Aurelio Palazzi Safadi, Soledad Urzua, Heather J Zar, Pierre Goussard, Barry Rodgers-Gray, Nicola Waghorne, Manuel Sanchez Luna

Affiliations

  • Department of Public Health and Pediatric Sciences, University of Torino School of Medicine, Turin, Piedmont, Italy.
  • Division of Paediatrics and Neonatology, Degli Infermi Hospital, Ponderano, Italy.
  • Department of Women's and Children's Health, University Hospital of Padova, Veneto, Italy.
  • Institute of Pediatric Research, "Città della Speranza", Padova, Veneto, Italy.
  • Department of Pediatrics and Pediatric Neuropsychiatry, Sapienza University of Rome, Rome, Italy.
  • Hospices Civils de Lyon, Hôpital de la Croix Rousse, Service de néonatologie et réanimation néonatale, Bron, France.
  • EA 4129, Université Claude Bernard Lyon 1, Lyon, France.
  • Department of Pediatrics, University Hospital Centre, Zagreb, Croatia.
  • Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
  • The Neonatal Unit, Royal Stoke University Hospitals, Stoke-on-Trent, UK.
  • Department of Pediatrics (Neonatal Division), McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada.
  • Neonatology Service, Hospital Clinic, Barcelona, Spain.
  • Department of Pediatrics, Lviv National Medical University, Lviv, Ukraine.
  • Department of Neonatology, Health Sciences University, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
  • Department of Pediatrics, Prince Sultan Military Medical City, Alfaisal University, Riyadh, Saudi Arabia.
  • Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.
  • Department of Pediatrics, KK Women's and Children's Hospital, Singapore.
  • Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan.
  • Department of Pediatrics, MacKay Memorial Hospital, Taipei, Taiwan.
  • Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada.
  • Department of Medical Management, National Institute of Health Children´s Hospital of Mexico Federico Gómez, Mexico City, Mexico.
  • President of the National Federation of Neonatology of Mexico, Mexico City, Mexico.
  • Division of Neonatology, Departments of Pediatrics, Instituto Universitario Hospital Italiano, Buenos Aires, Argentina.
  • Department of Pediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
  • Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
  • Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • SA Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
  • Department of Paediatrics and Child Heath, Stellenbosch University, Stellenbosch, South Africa.
  • Paediatric Pulmonology and Paediatric Intensive Care, Tygerberg Hospital, Parow, South Africa.
  • Violicom Medical Limited, Aldermaston, UK.
  • Neonatology Division, University General Hospital Gregorio Maranon, Complutense University of Madrid, Madrid, Spain.

Abstract

Background

Long-acting monoclonal antibodies (LAmAbs) could dramatically reduce the respiratory syncytial virus (RSV) disease burden in children if implemented using clear, evidence-based recommendations.

Methods

The ARMADA Taskforce-an international, multidisciplinary expert panel-undertook a systematic review to develop LAmAbs consensus recommendations for RSV disease prevention in children.

Results

The Taskforce recommends LAmAbs for all infants aged <8 months in the absence of maternal RSV vaccination, preterm infants (<37 weeks' gestational age) aged <12 months, and children <24 months with high-risk conditions. Seasonal LAmAb administration is recommended, although in RSV-endemic countries decisions should be made locally concerning administration year-round or with peak RSV incidences.

Conclusions

The Taskforce strongly endorses LAmAbs implementation based on their efficacy, effectiveness, and public health impact. These recommendations provide a blueprint to inform guidelines worldwide. Wider equitable access to LAmAbs at affordable prices, especially in low- and middle-income countries is needed to reduce the childhood RSV burden.

MeSH

Respiratory Syncytial Viruses, Antibodies, Aged, Viruses, Antibodies, Monoclonal, Child, Virus Diseases, Infant