Journal Article Review Epublish 1 citation
PubMed: 40722944 DOI: 10.3390/antiox14070840
Post-COVID Condition and Neuroinflammation: Possible Management with Antioxidants.
Antioxidants (Basel) 14(7)
Authors: Noemí Cárdenas-Rodríguez, Iván Ignacio-Mejía, César Miguel Mejía-Barradas, Daniel Ortega-Cuellar, Felipe Muñoz-González, Marco Antonio Vargas-Hernández, Exsal Manuel Albores-Méndez, Gabriela Ibáñez-Cervantes, Roberto Medina-Santillán, Aarón Hernández-Ortiz, Elizabeth Herrera-López, Cindy Bandala
Affiliations
- Laboratorio de Neurociencias, Instituto Nacional de Pediatriía, Secretariía de Salud, Mexico City 04530, Mexico.
- Sección de Investigación, Escuela Militar de Graduados de Sanidad, Centro de Investigación y Desarrollo del Ejército y Fuerza Aérea Mexicanos, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.
- Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
- Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
- Departamento de Investigación, Universidad Estatal del Valle de Ecatepec, Mexico City 55210, Mexico.
Abstract
Post-COVID condition (PCC) is a complex syndrome characterized by the persistence of diverse symptoms-including respiratory, neurological, and psychiatric manifestations-that last for weeks or months after acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Epidemiological data indicate a higher prevalence among women and older adults, with significant impacts on daily functioning. The pathophysiology of PCC is multifactorial, involving immune dysregulation, viral persistence, mitochondrial dysfunction, and oxidative stress, all of which contribute to sustained neuroinflammation. This narrative review examines the clinical features, risk factors, and current evidence on antioxidant-based interventions as potential therapeutic strategies for PCC. A wide range of compounds-including vitamins, polyphenols, and endogenous antioxidants-have shown promise in mitigating neuroinflammation and oxidative damage in both clinical and experimental settings. Antioxidants may help restore redox balance and improve neurological outcomes in affected patients. However, further clinical research is essential to determine their efficacy, safety, and optimal therapeutic protocols.
MeSH
Sars-Cov-2, Antioxidants, Therapeutics, Post-Acute Covid-19 Syndrome