Journal Article Review Epublish 2 citations
PubMed: 40723309 DOI: 10.3390/biology14070747
Redox Biology and Insulin-like Growth Factor-Binding Protein-6: A Potential Relationship.
Biology (Basel) 14(7)
Authors: Anna Rita Daniela Coda, Arcangelo Liso, Francesco Bellanti
Affiliations
- C.R.E.A.T. E-Center for Research and Innovation in Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
- Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Abstract
Insulin-like growth factor-binding protein 6 (IGFBP-6) is primarily recognized for its inhibitory effects on insulin-like growth factor 2 (IGF-2), regulating processes such as cell proliferation, differentiation, and survival. However, recent studies have revealed that IGFBP-6 also participates in a range of IGF-independent activities, notably in redox biology, immune regulation, and fibrosis. These IGF-independent actions involve interactions with redox-sensitive signaling pathways that influence mitochondrial metabolism, neutrophil function, and fibroblast activity, all of which are central to redox-dependent processes in inflammation and fibrosis. Despite these insights, the precise mechanisms by which IGFBP-6 modulates redox signaling remain largely unexplored. This review examines the growing understanding of IGFBP-6 beyond its classical role as an IGF-binding protein, with a focus on its involvement in redox homeostasis. By exploring these emerging roles, we aim to elucidate how IGFBP-6 contributes to redox homeostasis and to assess its potential as a therapeutic target in oxidative stress-related diseases, including fibrosis, cancer, and immune dysfunction.
MeSH
Growth, Insulin, Fibrosis, Homeostasis, Somatomedins, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 6