System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Observational Study Epublish

PubMed: 40723787 DOI: 10.3390/biom15070914

Inflammatory Drug-Resistant Epilepsy Index (IDREI) as a Molecular Compound Biomarker in Focal Epilepsies.

Biomolecules 15(7)

Authors: Maria José Aguilar-Castillo, Guillermo Estivill-Torrús, Guillermina García-Martín, Pablo Cabezudo-García, Yolanda López-Moreno, Jesús Ortega-Pinazo, Teresa Ramírez-García, Nicolas Lundahl Ciano-Petersen, Pedro Jesus Serrano-Castro

Affiliations

  • Servicio de Análisis Clínicos, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Instituto de Investigación Biomédica de Málaga y Plataforma de Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain.
  • Servicio de Neurología, Unidad de Neurociencias, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA), 29010 Málaga, Spain.
  • Instituto de Investigación Biomédica de Málaga y Plataforma de Nanomedicina-IBIMA Plataforma BIONAND, 29590 Málaga, Spain. Servicio de Neurología, Unidad de Neurociencias, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
  • Departamento de Medicina y Dermatología, Universidad de Málaga, 29010 Málaga, Spain.

Abstract

BACKGROUND

There is growing evidence that neuroinflammation is involved in epileptogenesis. Identifying its biomarkers can be important for distinguishing epilepsy patients from healthy individuals and differentiating well-controlled epilepsy from drug-resistant epilepsy (DRE).

METHODS

An observational case-control study at Malaga's Regional University Hospital involved epilepsy patients divided into three groups: healthy controls (HC), seizure-free epilepsy (SFE), and DRE. Demographic and clinical data and plasmatic and/or CSF levels of 24 different inflammation-related molecules were collected for each patient and were analyzed through univariate and multivariate analysis.

RESULTS

The study included 68 patients: 38 in the DRE group, 14 in the SFE group, and 16 in the HC group. A new Inflammatory Drug-Resistant Epilepsy Index (IDREI) was created using key variables with significant or trending significance. This index combined pro-inflammatory mediators (ICAM-1 and NfL) and anti-inflammatory factors (IL-10 and IL-4), showing statistical significance (p = 0.002). ROC curve analysis for the IDREI gave an AUC of 0.731 (95% CI: 0.608-0.854). A multivariate logistic regression model's ROC analysis resulted in a higher AUC of 0.891 (95% CI: 0.791-0.991).

CONCLUSIONS

The IDREI molecular index shows promise in predicting epilepsy and drug-resistant epilepsy (DRE). Additional prospective studies are required to assess its clinical utility.

MeSH

Drug Resistant Epilepsy, Epilepsy, Pharmaceutical Preparations, Epilepsies, Partial, Biomarkers, Roc Curve