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Publications

Journal Article Review Epublish

PubMed: 40724891 DOI: 10.3390/ijms26146641

Obesity-Related Kidney Disease: A Growing Threat to Renal Health.

Int J Mol Sci 26(14)

Authors: Juan León-Román, Marina López-Martínez, Alexandra Esteves, Andreea Ciudin, Sara Núñez-Delgado, Tiffany Álvarez, Albert Lecube, Jorge Rico-Fontalvo, María José Soler

Affiliations

  • Nephrology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Research, CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, Paseo de la Vall d´Hebron 119, 08035 Barcelona, Spain.
  • Department of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
  • Nephrology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Research, CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, Paseo de la Vall d´Hebron 119, 08035 Barcelona, Spain. Department of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
  • Nephrology Department, Hospitais da Univerisdade de Coimbra, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.
  • Endocrinology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Research, Diabetes and Metabolism Research Group, Paseo de la Vall d´Hebron 119, 08035 Barcelona, Spain.
  • CIBERDEM (Instituto de Salud Carlos III), 28029 Madrid, Spain.
  • Asociación Colombiana de Nefrología e HTA, Bogotá 0814, Colombia.
  • Facultad de Medicina, Departamento de Nefrología, Universidad Simón Bolívar, Carrera 59 Número 59-65, Barranquilla 111321, Colombia.

Abstract

Obesity represents a serious and growing disease worldwide. The pathophysiological changes secondary to chronic inflammation lead to the development of diseases that increase the morbidity and mortality of individuals. Chronic kidney disease (CKD) is a condition with deleterious effects that acts bidirectionally with obesity. From approximately 20% to 30% of individuals share phenotypes of CKD and obesity, increasing their cardiovascular risk and the risk of other complications. Obesity and CKD form a vicious cycle in which inflammation is the central axis of multiorgan damage. Despite increasing the risk of cardiac and renal mortality, CKD progresses in relation to body mass index and albuminuria. Nowadays, the implementation of the new medications aimed at mitigating the peak of inflammation is becoming a cornerstone of treatments for obesity, diabetes, cardiovascular diseases, and renal disease.

MeSH

Kidney Diseases, Mortality, Cardiovascular Diseases, Kidney, Obesity