Journal Article Review Epublish 1 citation
PubMed: 40725036 DOI: 10.3390/ijms26146789
Hurdles of Sperm Success: Exploring the Role of DNases.
Int J Mol Sci 26(14)
Authors: Jaime Gosálvez, Carmen López-Fernández, Javier Bartolomé-Nebreda, Carlos García de la Vega
Affiliations
- Unidad de Genética, Departamento de Biología, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
- Departamento de Investigación y Desarrollo, Halotech DNA S.L. Parque Científico de Madrid, 28049 Madrid, Spain.
Abstract
The incidence of sperm DNA fragmentation (SDF) in the ejaculate has garnered increasing attention in recent years due to its negative impact on reproductive outcomes. SDF involves two primary types of damage to the canonical double helix of DNA: single-strand breaks and double-strand breaks. Both of these can occur throughout the entire process of gametogenesis. Determining the precise causes of elevated SDF remains challenging, as it is influenced by a wide range of physiological processes and environmental factors. This review comprehensively explores the mechanisms underlying SDF, with a particular emphasis on the critical role of deoxyribonucleases (DNases) across different stages of male gamete development, as well as their relevance in assisted reproductive technologies (ART).
MeSH
Infertility, Spermatozoa