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Publications

Journal Article Epublish

PubMed: 40727806 DOI: 10.1021/acsomega.5c03218

In-Vitro Bioactive Silver Nanoparticles Synthesized from Plant Extract for Multifunctional Drug Delivery.

ACS Omega 10(28):30851-30863

Authors: Murugeswaran Santhiya Selvam, Pious Soris Tresina, Ramakrishnan Rajalakshmi, Solomon Jeeva, Lakshminarasimhan Rajeshkumar, Vallinayagam Sornalakshmi, Veerabahu Ramasamy Mohan, Mathiyazhagan Sathishkumar

Affiliations

  • PG Department of Botany, Kamaraj College, Tuticorin, Tamil Nadu 628003, India.
  • Ethnopharmacology & Green Synthesis Unit, PG & Research Department of Botany, V.O. Chidambaram College, Tuticorin, Tamil Nadu 628008, India.
  • PG & Research Department of Botany, Scott Christian College, Nagercoil, Tamil Nadu 629003, India.
  • CoE-Advanced Materials Synthesis (AU-STIC) and Department of Mechanical Engineering, Alliance College of Applied Engineering, Alliance University, Bangalore, Karnataka 562106, India.
  • Department of Botany, A.P.C. Mahalaxmi College for Women, Tuticorin, Tamil Nadu 628002, India.
  • Department of Mechanical Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Chennai, Tamil Nadu 601103, India.

Abstract

The synthesis of AgNPs (silver nanoparticles) was performed using the aqueous extract of seagrass (HU) along with silver nitrate. The synthetic production of HU-AgNPs was confirmed by a color change and analyzed with a UV-vis spectrophotometer at 450 nm. The existence of functional groups was verified using Fourier transform infrared (FTIR) spectroscopy. The HU-AgNPs' spherical shape was validated by scanning electron microscopy (SEM) tests. The crystal structure of HU-AgNPs was established by X-ray diffraction (XRD). The roughness and surface morphology were confirmed by atomic force microscopy (AFM). Significant antibacterial action was demonstrated by the HU-AgNPs against and , two Gram-negative pathogens. The antioxidant showed the highest inhibition of ABTs (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) when compared to hydroxyl scavenging, 2,2'-diphenyl-2-picrylhydroxyl (DPPH), hydrogen peroxide (H 2O 2), nitric oxide (NO), and superoxide tests. By inhibiting α-amylase along with α-glycosidase, the HU-AgNPs' antidiabetic effectiveness was evaluated. Therefore, to validate the findings and create an antibacterial, anti-inflammatory, antioxidant, and antidiabetic drug, a molecule-level in vivo study is required. Such synthesized nanoparticles have potential applications in multifunctional drug delivery applications.

MeSH

Plant Extracts, Microscopy, Atomic Force, Peroxides, Nanoparticles, Pharmaceutical Preparations, Antioxidants, Microscopy