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Publications

Journal Article Epublish 1 citation

PubMed: 40733164 DOI: 10.3390/molecules30142896

New 3D Spiral Microfluidic Platform Tested for Fe 3O 4@SA Nanoparticle Synthesis.

Molecules 30(14)

Authors: Elena-Theodora Moldoveanu, Adelina-Gabriela Niculescu, Dana-Ionela Tudorache Trifa, Alina Moroșan, Alexandra-Cătălina Bîrcă, Bogdan-Ștefan Vasile, Ariana Hudita, Dan-Eduard Mihaiescu, Tony Hadibarata, Alexandru-Mihai Grumezescu

Affiliations

  • Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
  • Department of Organic Chemistry, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
  • Research Center for Advanced Materials, Products and Processes, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.
  • National Research Center for Micro and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.
  • Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei Street, 050095 Bucharest, Romania.
  • Environmental Engineering Program, Faculty of Engineering and Science, Curtin University Malaysia, CDT 250, Miri 98009, Malaysia.

Abstract

Due to the need for reproducible, scalable, and environmentally friendly nanomaterial synthesis methods, an increasing amount of scientific interest revolves around microfluidic technologies. In this context, the present paper proposes a new three-dimensional (3D) spiral microfluidic platform designed and tested for the simultaneous synthesis and surface functionalization of magnetite (Fe 3O 4) nanoparticles with salicylic acid (SA). The microreactor was fabricated from overlaid polymethylmethacrylate (PMMA) sheets and assembled into a compact, reusable chip architecture, allowing continuous reagent mixing and enhanced hydrodynamic control. The performed physicochemical analyses confirmed that on-chip synthesized Fe 3O 4@SA NPs exhibit crystallinity, a uniform spherical morphology, a narrow size distribution, excellent colloidal stability, and successful surface functionalization. In vitro cytotoxicity assays using MRC-5 lung fibroblasts and HaCaT keratinocytes revealed a concentration-dependent response, identifying a safe dose range below 610 µg/mL. The integrated design, efficient synthesis, and favorable biocompatibility profile position this 3D microfluidic platform as a promising tool for scalable nanomaterial production in biomedical and environmental applications.

MeSH

Nanoparticles, Nanostructures, Microfluidics, Polymethyl Methacrylate, Salicylic Acid