Journal Article Review Epublish
PubMed: 40746532 DOI: 10.3389/fimmu.2025.1583274
Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation.
Front Immunol 16:1583274
Authors: Xuan Sun, Jiayan Wang, Hao Gu, Maojuan Guo, Zhen Yang
Affiliations
- Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
- College Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
- Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
- School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
- School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Abstract
Ischemic stroke, characterized by high clinical mortality and poor prognosis, has been prioritized by the World Health Organization (WHO) for reducing the burden of non-communicable diseases. However, the pathogenesis of ischemic stroke remains complex and poorly understood. Recent studies have revealed the infiltration of γδ T cells within ischemic stroke lesions, accompanied by the upregulation of IL-17, IL-23, and other inflammatory cytokines, suggesting their involvement in the stroke's pathological process. Literature indicates that γδ T cells are recruited to the lesion site by microglia-derived chemokines and subsequently infiltrate the damaged brain tissue. This review summarizes current knowledge on the precise mechanisms underlying γδ T cell activation, migration, and ensuing immune-inflammatory responses in neuroinflammation, as well as their role in the progression of ischemic stroke. It further discusses the therapeutic potential of targeting γδ T cells to modulate neuroinflammation for ischemic stroke treatment, thereby offering novel therapeutic targets for managing neuroinflammation in this condition.
MeSH
Microglia, Cells, Ischemic Stroke, Stroke, Therapeutics, Neurology