Journal Article Review Epublish
PubMed: 40765836 DOI: 10.7150/ijbs.115359
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease.
Int J Biol Sci 21(10):4374-4387
Authors: Hua Miao, Shui-Juan Zhang, Xin Wu, Ping Li, Ying-Yong Zhao
Affiliations
- School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China.
- School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
- Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, Department of Nephrology, China-Japan Friendship Hospital, Beijing, 100029, China.
- School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Abstract
Aromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology. Tryptophan metabolism is involved in the regulation of aging, immunity and intestinal homeostasis. Dysregulation of tryptophan metabolism ranging from bowel disease to kidney disease allow us to therapeutic targeting the tryptophan metabolism. This review summarizes recent advances in physiological and pathophysiological roles of tryptophan metabolism in health and disease such as ageing-related disease, bowel disease and renal disease. Decoding the sophisticated imbalance between tryptophan metabolism pathways will expedite a comprehensive understanding of the pathogenesis of human diseases and highlight the opportunities and challenges for medication research and development in multiple diseases. This review presents concept-driven diagnostic and therapeutic strategies for the management of patients with kidney disease by gut-kidney-aging axes.
MeSH
Kidney Diseases, Receptors, Aryl Hydrocarbon, Tryptophan, Aging, Kidney, Therapeutics, Gastrointestinal Microbiome, Microbiota