System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Epublish

PubMed: 40769534 DOI: 10.1183/16000617.0228-2024

CD146: a promising target in respiratory diseases.

Eur Respir Rev 34(177)

Authors: Julien Bermudez, Florian Lepretre, Charlotte Reytier, Xavier Heim, Kim Valette, Ahmad Joshkon, Benjamin Coiffard, Aurélie Leroyer, Delphine Gras, Marcel Blot-Chabaud, Pascal Chanez, Martine Reynaud-Gaubert, Nathalie Bardin

Affiliations

  • APHM, North Hospital, Department of Respiratory Medicine, Marseille, France.
  • Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France.
  • Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France. APHM, La Timone Hospital, Biological immunology department - BiogĂ©nopĂ´le, Marseille, France.
  • APHM, La Timone Hospital, Biological immunology department - BiogĂ©nopĂ´le, Marseille, France.
  • APHM, North Hospital, Department of Respiratory Medicine, Marseille, France.
  • Massalia Therapeutics, Marseille, France.

Abstract

Respiratory diseases are major causes of chronic disorders and death worldwide, involving inflammatory, tumoral or infectious processes. It has been proven that vascular mechanisms are key contributors to the pathogenesis of these diseases. For that purpose, it is essential to describe and validate new biomarkers and/or therapeutic targets responsible for lung vascularisation and/or angiogenesis. CD146 is an endothelial cell adhesion molecule also expressed on mesenchymal stem cells, epithelial cells and T-helper 17 lymphocytes. A soluble form of CD146 exists, sCD146, which can be detected in blood and biological samples, including the bronchoalveolar lavage fluid. CD146/sCD146 are involved in angiogenesis and inflammation and are associated with many inflammatory diseases. Recent studies have reported both protective and detrimental roles of CD146/sCD146 in lung diseases. In the present review, we will describe the potential role of CD146 and sCD146 in the pathogenesis of respiratory diseases in order to use them as key mechanistic biomarkers or new therapeutical targets to treat or even cure these pathologies.

MeSH

Cells, Lung, Epithelial Cells, Biomarkers, Therapeutics, Angiogenesis