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Publications

Journal Article Epublish

PubMed: 40771983 DOI: 10.3389/fneur.2025.1558196

Anti-neuroinflammatory therapy for non-pulsatile tinnitus in patients with sinus vascular anomalies: preliminary result on two cases.

Front Neurol 16:1558196

Authors: Arianna Di Stadio, Daniela Messineo, Iole Indovina, Giovanni Motta, Massimo Ralli, Michael J Brenner

Affiliations

  • Department of Otolaryngology, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Dipartimento di Scienze Radiologiche, Oncologiche ed Anatomo Patologiche, University La Sapienza, Rome, Italy.
  • Department of Systems Medicine and Centre for Space BioMedicine, University of Rome Tor Vergata, Rome, Italy.
  • International Medical University, Unicamillus, Rome, Italy.
  • Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, United States.

Abstract

Background

Vascular anomalies are commonly associated with pulsatile tinnitus, but their potential role in triggering non-pulsatile tinnitus through neuroinflammation is not well established. Furthermore, few studies have investigated non-pulsatile tinnitus associated with altered cerebrovascular supply and whether anti-neuroinflammatory therapy might alleviate symptoms.

Materials and methods

We describe two patients presenting with non-pulsatile tinnitus and sigmoid sinus stenosis confirmed by imaging, with other causes systematically excluded.

Results

Magnetic resonance venography demonstrated severe stenosis of the transverse and sigmoid sinuses, alongside compensatory ipsilateral vascular dilatation. These structural abnormalities suggested disrupted venous blood flow, contributing to the neuroinflammatory processes associated with non-pulsatile tinnitus. Following treatment with an anti-inflammatory molecule, both patients reported a substantial reduction in tinnitus severity.

Conclusion

This study supports the potential of anti-inflammatory treatments in managing non-pulsatile tinnitus linked to sinus vascular anomalies. Further research is warranted to elucidate these relationships and confirm therapeutic efficacy of anti-inflammatory agents.

MeSH

Tinnitus, Constriction, Pathologic, Colon, Sigmoid, Therapeutics