Journal Article Review Ppublish 18 citations
PubMed: 40783929 DOI: 10.1021/acsmacrolett.5c00417
Biodegradable Polyesters: Approaches to Increase Degradation Rates for Biomedical Applications.
ACS Macro Lett 14(8):1221-1240
Authors: Courteney T Roberts, Melissa A Grunlan
Affiliations
- Department of Biomedical Engineering Texas A&M University, College Station, Texas 77843-3003, United States.
- Department of Biomedical Engineering, Department of Materials Science & Engineering, Department of Chemistry Texas A&M University, College Station, Texas 77843-3003, United States.
Abstract
The rate of biodegradation of polyesters is essential to their utility in biomedical applications but is frequently undesirably slow, prompting significant interest in overcoming this limitation. Herein, we highlight passive, enzyme-mediated, and load-mediated mechanisms of the hydrolytic degradation of polyesters. Exemplified by recent reports, strategies to impart accelerated rates of degradation are discussed, including synthetic routes, 3D systems, and processing methods. Approaches to assess polyester degradation in vitro and in vivo are summarized, underscoring the need for careful consideration of testing parameters and the challenges arising from testing variability employed within the reported literature. Recent reports also highlight faster-degrading polyester systems for targeted biomedical applications, including regenerative engineering, drug delivery, women's health, and other medical devices. Overall, polyesters with accelerated rates of degradation will afford tremendous opportunities in bioresorbable devices and therapeutics.
MeSH
Research Design, Polyesters