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Publications

Journal Article Review Epublish 26 citations

PubMed: 40796868 DOI: 10.1186/s12951-025-03602-9

Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives.

J Nanobiotechnology 23(1):563

Authors: Kingsley Miyanda Tembo, Xiaohui Wang, Mansoor Bolideei, Qianrui Liu, Farouk Baboni, Mohammad Javad Mehran, Fei Sun, Cong-Yi Wang

Affiliations

  • The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Healit Research International/TRACE Research, Untold Global Healit Zambia, Lusaka, Zambia.
  • The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
  • The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Department of Immunology, Chabahar faculty of Medical Sciences, Chabahar, Iran.
  • Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Department of Biotechnology, JSS Research Foundation, SJCE Technical Campus, University of Mysore, Karnataka, 570006, India.
  • Tongji Shanxi Hospital, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province, Shanxi Medical University, Taiyuan, China. The Center for Biomedical Research, NHC Key Laboratory for Respiratory Diseases, Tongji Hospital Research Building, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar.

Abstract

Exosomes, nano-sized extracellular vesicles, facilitate intercellular communication by transferring biomolecules such as microRNAs (miRNAs), which are key regulators of gene expression. While mammalian-derived exosomes (MDEs) have shown therapeutic promise, their clinical application has been limited by challenges such as immune-related toxicities, low yield and high production costs. In contrast, plant-derived exosome-like nanoparticles (PELNs) offer a sustainable, biocompatible, and cost-effective alternative, encapsulating a diverse array of bioactive miRNAs with significant therapeutic potential. Studies have demonstrated the ability of PELN-derived miRNAs in cross-kingdom communication, effectively transferring into mammalian cells, where they modulate disease-related pathways, including cancer, inflammation, metabolism, and neurodegeneration. This review explores the bioactivity of plant-derived miRNAs, highlighting their role as novel therapeutic agents. The study explores the bioactivity and potential mechanisms by which these miRNAs influence human cellular processes, focusing on their ability to regulate gene expression in different tissues. Additionally, the study examines recent advances in PELN research, emphasizing their potential for clinical translation in precision medicine, and highlights challenges and future prospects in harnessing the therapeutic capabilities of these bioactive miRNAs. This review underscores the potential of PELNs to revolutionize therapeutic strategies, offering a sustainable, biocompatible, and cost-effective platform for targeted miRNA delivery, paving the way for innovative interventions leveraging nature's own nanocarriers.

MeSH

Genes, Nanoparticles, Micrornas, Communication, Exosomes, Therapeutics, Nanotechnology, Gene Expression