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Publications

Journal Article Review Epublish

PubMed: 40804626 DOI: 10.1186/s12933-025-02863-w

Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy.

Cardiovasc Diabetol 24(1):332

Authors: Yingjie Feng, Yajing Wang, Yifan Deng, Peifen Li, Penghua Fang, Zhenwen Zhang

Affiliations

  • Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China. Department of Endocrinology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
  • Department of Cardiovascular, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
  • Medical College, Yangzhou University, Yangzhou, 225001, China.
  • Key Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China. Department of Endocrinology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.

Abstract

Diabetic cardiomyopathy (DCM) is a prevalent complication in diabetic patients, and its pathogenic mechanism involves multiple endocrine and metabolic factors, with dyslipidemia playing a pivotal role in the pathogenesis of the disease. Recent studies have highlighted the importance of peptides in energy metabolism and their potential effect on the onset and development of DCM by affecting the function of perivascular adipose tissue (PVAT). The present review aims to examine the effect of these peptides on perivascular adipose tissue and myocardial metabolism during the pathogenesis of DCM, focusing on the role of peptides distributed in perivascular adipose tissue in cardioprotection and their underlying mechanisms of action. In addition, we will explore future research directions and potential clinical applications of these peptides in the treatment of DCM.

MeSH

Diabetic Cardiomyopathies, Adipocytes, Tissues, Diabetes Complications, Cardiomyopathies, Adipose Tissue