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Publications

Journal Article Epublish

PubMed: 40806171 DOI: 10.3390/ijms26157039

The Effect of Statin Therapy on Hemorheological Parameters of Patients with Clinically Silent Ischemic Foci of the Brain.

Int J Mol Sci 26(15)

Authors: Anna Marcinkowska-GapiƄska, Izabela Siemieniak

Affiliations

  • Department of Biophysics, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
  • Rheological Laboratory, Department of Neurology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Abstract

Hemorheology is a branch of science that studies and explains the causes of blood flow disorders. In many vascular disorders whole blood viscosity, plasma viscosity, aggregability, and deformability of erythrocytes can be a diagnostic factor. In this paper we analyze whether statin therapy affects hemorheological values in a group of patients with clinically diagnosed silent ischemic foci of the brain (CSVCL). The study includes an analysis of the hemorheological parameter values such as whole blood viscosity, plasma viscosity, and selected biochemical parameters. Aggregability and deformability of erythrocytes were determined using the mathematical Quemada model. Our results indicate a modifying effect of statins on hemorheological parameters.

MeSH

Blood Viscosity, Erythrocytes, Blood, Brain, Therapeutics, Hydroxymethylglutaryl-Coa Reductase Inhibitors, Hemorheology, Plasma