Journal Article Review Epublish
PubMed: 40806212 DOI: 10.3390/ijms26157079
Research Progress on the Effect of Thesium chinense Turcz. on Neurodegenerative Diseases.
Int J Mol Sci 26(15)
Authors: Ziyi Li, Yanfang Zhao, Rong Wang, Ruoxuan Zhou, Xuehua Chen, Jingchen Jiang, Yilan Dai, Huaiqing Luo
Affiliations
- Department of Physiology, School of Basic Medical Sciences, Hunan Normal University, Changsha 410013, China.
- Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University, Changsha 410013, China.
- College of Life Sciences, Hunan Normal University, Changsha 410013, China.
- Department of Physiology, School of Basic Medical Sciences, Hunan Normal University, Changsha 410013, China. Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University, Changsha 410013, China.
Abstract
Thesium chinense Turcz., a traditional Chinese medicinal herb, is enriched with bioactive constituents such as flavonoids and polysaccharides, demonstrating multifaceted therapeutic properties including anti-inflammatory, antioxidant, and neuroprotective effects. This review systematically elucidates the regulatory mechanisms by which active components of Thesium chinense Turcz. modulate pathological processes in NDDs, such as neuroinflammation and oxidative stress. Furthermore, it synthesizes evidence of its neuroprotective efficacy across experimental models and evaluates its translational potential for clinical applications. By integrating preclinical findings and mechanistic insights, this work provides a robust theoretical foundation for advancing natural product-based therapeutics in the management of NDDs.
MeSH
Antioxidants, Research, Therapeutics, Neurodegenerative Diseases