Journal Article Review Epublish
PubMed: 40809518 DOI: 10.3389/fcimb.2025.1641405
The diagnostic potential of extracellular vesicles in virus-related diseases.
Front Cell Infect Microbiol 15:1641405
Authors: Qing Gao, Yuqing Zhan, Jianhao Zhang, Dongyu Sun, Huayuan Xiang, Chenxuan Bao, Qianqian Gao, Mengyu Zhang, Jianjun Wang, Lingxiang Mao
Affiliations
- Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu university, Zhenjiang, Jiangsu, China.
- Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.
- Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu university, Zhenjiang, Jiangsu, China.
Abstract
Extracellular vesicles (EVs), a heterogeneous population of lipid bilayer-enclosed membranous particles, are widely involved in cell-cell communication and pathophysiological regulation. Recent advances reveal their dual functionality in viral pathogenesis: while facilitating viral dissemination through transport of pathogenic components, they simultaneously orchestrate host antiviral defense mechanisms. The unique molecular cargo loading capacity and high stability of EVs in body fluids make them ideal biomarkers for early infection diagnosis, treatment monitoring, and prognostic evaluation of virus-related disease. Compared to traditional viral detection methods, EV-based liquid biopsy techniques exhibit distinct advantages, including non-invasiveness and enhanced sensitivity thresholds. This review systematically examines the diagnostic potential of EV biomarkers in viral infections, offering novel perspectives for developing precision diagnostics and therapeutic interventions.
MeSH
Cells, Extracellular Vesicles, Biomarkers, Cell Biology, Viruses, Diagnosis, Therapeutics, Infections