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Publications

Journal Article Review Epublish 11 citations

PubMed: 40817227 DOI: 10.1186/s11658-025-00776-w

Palmitoylation: an emerging therapeutic target bridging physiology and disease.

Cell Mol Biol Lett 30(1):98

Authors: Weini Li, Jie Shen, Aojia Zhuang, Ruiheng Wang, Quanqi Li, Anas Rabata, Yanan Zhang, DuoYao Cao

Affiliations

  • Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90067, USA.
  • Department of GI Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, 91010, USA.
  • School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China.
  • Pulmonary Division in the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90067, USA.
  • Department of Cell Engineering, Beijing Institute of Biotechnology, Beijing, 100850, China.
  • International Center for Aging and Cancer, Department of Hematology of The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.
  • Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90067, USA.

Abstract

Palmitoylation is a reversible post-translational lipid modification of proteins, catalyzed by the Zinc finger DHHC domain-containing (ZDHHC) family of palmitoyltransferases. Palmitoylation plays a pivotal role in regulating localization, stability, trafficking, and interactions, thereby contributing to a wide range of cellular processes. Dysregulation of palmitoylation has been implicated in numerous pathological conditions, including metabolic disorders, muscular diseases, mitochondrial disorders, cancer, and neurodegeneration. In this review, we summarize recent advances in understanding S-palmitoylation, emphasizing its critical roles in protein regulation, cellular and physiological processes, and its implications in both health and disease. Additionally, we highlight emerging therapeutic opportunities and novel strategies in therapeutic applications targeting this lipid modification.

MeSH

Cells, Physiology, Biophysics, Molecular Biology, Therapeutics