Journal Article Review Ppublish
PubMed: 40817451 DOI: 10.1080/21505594.2025.2541711
Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways.
Virulence 16(1):2541711
Authors: Penghao Lv, Zhichao Wang, Haowei Chen, Yanru Chen, Hanlin Liao, Kaiyue Wei, Shuying Lv, Min Cui
Affiliations
- State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China. Cooperative Innovation Center for Sustainable Pig Production, Hubei Jiangxia Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
- Department of English Teaching and Research Section, Dongying Vocational College, Dongying, China.
Abstract
African swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs), with a particular focus on viral evasion strategies that disrupt antigen presentation pathways. Although current understanding of ASFV immunology has largely focused on monocyte/macrophage infection, we provide a systematic analysis of ASFV-mediated immunosuppression across various APCs, including dendritic cells (DCs), B lymphocytes, and γδ T cells, and compare these mechanisms with those employed by other viral pathogens. Key objectives include: (1) synthesizing ASFV-induced dysregulation of antigen presentation, (2) identifying critical gaps in APC-virus interactions, and (3) guiding vaccine development priorities. By highlighting understudied DC-ASFV interplay and potential molecular targets, this work provides a strategic framework for next-generation vaccine design based on host-pathogen conflict at the antigen presentation interface.
MeSH
Cells, African Swine Fever Virus, Classical Swine Fever Virus, Vaccines, Adaptive Immunity, Antigen Presentation, Work, Viruses, African Swine Fever, Virulence, Classical Swine Fever