Journal Article Ahead of print
PubMed: 41025386 DOI: 10.1002/mds.70071
Longitudinal Blood-Biomarker-Based Assessment of Brain Injury in Patients Undergoing Deep Brain Stimulation and Magnetic Resonance-Guided Focused Ultrasound.
Mov Disord
Authors: Justina Dargvainiene, Ann-Kristin Helmers, Juliana Naumann, Carl Alexander Gless, Bettina Möller, Julius Welzel, Frank Leypoldt, Johannes Hensler, Ina Tesseur, Klaus-Peter Wandinger, Günther Deuschl, Daniela Berg, Steffen Paschen
Affiliations
- Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Kiel, Germany.
- Department of Neurosurgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
- Department of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
- Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
- UCB, Braine-l'Alleud, Belgium.
Abstract
BACKGROUND
Deep brain stimulation (DBS) and magnetic resonance-guided focused ultrasound (MRgFUS) are associated with neuroaxonal damage and astroglial activation; yet their extent and timing remain unclear despite clinical relevance for monitoring and outcome assessment.
OBJECTIVE
This study assessed neuroaxonal damage and astroglial activation after DBS (n = 21) and MRgFUS (n = 19) reflected by serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP).
METHODS
Samples were collected at baseline, 24 h, 7 days, and 3/6/9 months posttreatment. Biomarker levels were measured using a single-molecule array (Simoa).
RESULTS
sNfL peaked at day 7 and sGFAP at 24 h post-intervention in both groups. sNfL normalized at 6 months in DBS and 3 months in MRgFUS. sGFAP normalized within 7 days in both groups. Biomarker elevations were higher in DBS patients.
CONCLUSIONS
DBS and MRgFUS cause transient neuroaxonal injury and astroglial activation, with greater extent in DBS. Biomarker monitoring suggests final clinical evaluation should be performed 6 months after treatment at the earliest. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
MeSH
Brain Injuries, Blood, Serum, Brain, Biomarkers, Movement Disorders, Deep Brain Stimulation, Therapeutics