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Publications

Journal Article Ahead of print

PubMed: 41102969 DOI: 10.2174/0115734021394152250922224959

Hypertension and Intracranial Hypertension Association: A Narrative Review.

Curr Hypertens Rev

Authors: Mikaelle Costa Correia, Sayuri Inuzuka, Matheus Martins da Costa, Priscila Valverde de Oliveira Vitorino, Polyana Vulcano de Toledo Piza, Gustavo Frigieri, Ana Luiza Lima Sousa, Antonio Coca, Weimar Kunz Sebba Barroso

Affiliations

  • Hypertension Unit, Cardiovascular Section and Health Sciences Post Graduation Program. Federal University of Goias, Goiania, GO, Brazil.
  • Pontifical Catholic University of Goias, Brazil.
  • Hospital Israelita Albert Einstein, Goiânia, Goiânia, Brazil.
  • brain4care, São Paulo, SP, Brazil.
  • Medical Investigation Laboratory 62, University of São Paulo School of Medicine, São Paulo, Brazil.
  • School of Health and Life Sciences, Universitat Abat Oliba CEU, CEU Universities, Barcelona, Spain.
  • School of Medicine, Clinical Hospital EBSERH, Federal University of Goias. Goiania, Brazil.

Abstract

Hypertension and intracranial hypertension are associated with distinct clinical contexts, encompassing both neurological and cardiovascular implications. Hypertension induces significant structural and functional alterations in cerebral arteries, such as vascular wall thickening, increased arterial stiffness, reduced vascular compliance, and endothelial dysfunction, all of which can contribute to elevated intracranial pressure. These vascular changes may impair the integrity of the blood-brain barrier and disrupt cerebral autoregulation, thereby diminishing the brain's ability to effectively regulate cerebral blood flow in response to physiological demands. The persistence of these dysfunctions over time may increase the risk of neurological outcomes, including stroke, cerebral edema, and cognitive impairment. Intracranial hypertension in turn may remain subclinical in patients with chronic hypertension, particularly when there is a gradual loss of intracranial compliance. This potential link highlights the need for further studies on the topic. Emerging evidence points to advances in noninvasive techniques for intracranial hypertension assessment, which may enable the early identification of altered intracranial dynamics and promote broader clinical application. Although the association between hypertension and intracranial hypertension has not yet been fully elucidated, the literature suggests overlapping mechanisms that may be clinically relevant. Combined assessment of blood pressure and intracranial parameters could represent a complementary strategy for better understanding cerebrovascular risk in selected populations. In this narrative review, we discuss the potential association between hypertension and intracranial hypertension, emphasizing their pathophysiological connections, contributing risk factors, and potential consequences for brain structure and function. Further research is needed to clarify these associations and their implications in clinical practice.

MeSH

Hypertension, Blood, Stroke, Brain, Cognitive Dysfunction, Cerebrovascular Disorders, Intracranial Hypertension