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Publications

Journal Article Ppublish

PubMed: 41189261 DOI: 10.1097/MD.0000000000045003

Reducing astigmatism following accelerated transepithelial corneal collagen cross-linking for keratoconus: A prospective study.

Medicine (Baltimore) 104(42):e45003

Authors: Reny Setyowati, Rifa Widyaningrum, Supanji Supanji, Khadijah Zai, Agus Supartoto

Affiliations

  • Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
  • Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Abstract

The purpose of this study was to evaluate the functional and corneal structural outcomes in the young population of keratoconus before and after accelerated transepithelial corneal collagen cross-linking (ATE-CXL) at 9 mW/cm2 for 10 minutes. In this prospective cohort study, ATE-CXL was performed on 36 eyes. The best-corrected visual acuity, spheris, astigmatism, K1, K2, Kmean, central corneal thickness, and intraocular pressure (IOP) were all evaluated. The follow-up time ranged from 2 weeks to 6 months after the procedure. The best-corrected visual acuity results improved significantly from 2 weeks (P <.001), 1.5 months (P <.001), and at 6 months postoperation (P <.001). ATE-CXL significantly reduced the patients' astigmatism after 6 months (P = .03). Following the procedure, there was a modest reduction in the K1, K2, and Kmean in the keratoconus patients. The intraocular pressure and central corneal thickness did not differ significantly at different time points. No postoperative complications were discovered following the procedure. ATE CXL demonstrated an early improvement in the patients' visual acuity and astigmatism in the Indonesian young population, and it was regarded as a safe and efficient keratoconus treatment. Further research with larger sample sizes and longer follow-up periods are required to confirm these findings.

MeSH

Keratoconus, Astigmatism, Collagen, Visual Acuity, Prospective Studies, Intraocular Pressure