Case Reports Journal Article Ppublish 1 citation
PubMed: 41314711 DOI: 10.1016/j.jaccas.2025.105780
Right Ventricular Volume Unload: Transcatheter Tricuspid Valve Replacement in Congenital Heart Disease.
JACC Case Rep 30(38):105780
Authors: Robin Le Ruz, David Stevant, Laurianne Le Gloan, Quentin Bernard, Pierre-Guillaume Piriou, Jean-Michel Serfaty, Damien Minois, Thomas Senage, Johann Clouet, Vincent Letocart, Thibaut Manigold, Karine Warin-Fresse, Julien Plessis, Patrice Guerin
Affiliations
- Nantes Université, CHU Nantes, l'institut du thorax, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
- Nantes Université, CHU Nantes, l'institut du thorax, Nantes, France.
- Nantes Université, CHU Nantes, l'institut du thorax, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
- Department of Radiology, Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
- Nantes Université, CHU Nantes, Service de chirurgie thoracique et cardiovasculaire, Unité de transplantation thoracique, l'institut du thorax, Nantes, France.
- Nantes Université, ONIRIS, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR1229, Nantes, France.
Abstract
BACKGROUND
The population of adults with repaired congenital heart disease is increasing, and given their frequent history of repeated surgeries, they are the ones that may benefit the most from less-invasive therapeutic options, in order to truly address their disease with a lifespan-management perspective. Tetralogy of Fallot patients frequently present with significant tricuspid regurgitation which has been associated with adverse clinical events.
CASE SUMMARY
We report hereinafter on a successful transcatheter tricuspid valve replacement (TTVR) in a middle-age Tetralogy of Fallot patient at high surgical risk. Our aim is to emphasize on the technical challenges but also on the major benefits of the procedure, either from a symptomatic or structural remodeling standpoint.
DISCUSSION
TTVR represents a promising therapy for this underserved subgroup of patients.
TAKE-HOME MESSAGES
TTVR in Tetralogy of Fallot patients is feasible. Despite the frequent advanced and chronic right ventricular adverse remodeling observed in this population, those patients may derive a great benefit from the procedure. Right ventricular reverse remodeling was associated with major symptomatic and functional improvement.
MeSH
Heart Defects, Congenital, Heart Diseases, Heart, Tricuspid Valve, Therapeutics, Tricuspid Valve Insufficiency