Journal Article Ahead of print
PubMed: 41537371 DOI: 10.1097/HJH.0000000000004239
The expanding role of Nogo-B in hypertension: linking kidney physiology, endothelial function and inflammation.
J Hypertens
Authors: Filipy Borghi, Yannan Jiang, Luigi Gnudi
Affiliations
- School of Cardiovascular and Metabolic Medicine & Science, section Vascular Biology and Inflammation, British Heart Foundation Centre of Research Excellence, King's College London.
- Department of Diabetes and Endocrinology, Guy's and St Thomas' Hospital, London, UK.
Abstract
Although Nogo-B has been studied in neural development and vascular biology, its integrative role across renal, vascular and inflammatory pathways in hypertension has not yet been systematically reviewed. Here, we synthesize emerging evidence positioning Nogo-B as a central modulator of blood pressure control. Its expression in the aldosterone-sensitive distal nephron and vascular endothelium suggests a central role in electrolyte and fluid balance, as well as vascular physiology. By bridging insights from the renal, vascular and immune systems, we position Nogo-B as an emerging contributor to blood pressure regulation and highlight its potential both as a biomarker for vascular dysfunction and as a therapeutic target in salt-sensitive and treatment-resistant hypertension.
MeSH
Hypertension, Physiology, Blood, Epithelial Sodium Channels, Blood Pressure, Kidney, Endoplasmic Reticulum, Therapeutics, Lipopolysaccharides, Nitric Oxide Synthase Type Iii