Journal Article Epublish
PubMed: 41704797 DOI: 10.1016/j.rpth.2026.103358
Patient-reported outcomes after upper-extremity deep vein thrombosis due to compression syndromes: a multinational longitudinal retrospective study.
Res Pract Thromb Haemost 10(1):103358
Authors: Maya Abrishami Kashani, Domenico Baccellieri, Mert Dumantepe, Naomi Elbaranes, Nicolas Gendron, Marianna Gigliotti De Fazio, Egidio Imbalzano, Lina Khider, Nils Kucher, Corrado Lodigiani, Benedetta Madaro, Saskia Middeldorp, Clara Sacco, Yasmine Terbeche, Ferdinando Benito Attilio Valente, Stefano Barco
Affiliations
- Department of Angiology, University Hospital Zurich, Zurich, Switzerland.
- Vascular Surgery Department, IRCCS H. San Raffaele, Milan, Italy.
- Department of Cardiovascular Surgery, Uskudar University School of Medicine, Istanbul, Turkey.
- Hematology Department, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris-Centre Université Paris Cité (APHP-CUP), F-75015 Paris, France.
- Paris Cité University, INSERM, Paris Cardiovascular Research Centre, Team Endotheliopathy and Hemostasis Disorders, Paris, France.
- F-CRIN INNOVTE, F-42000 Saint-Étienne, France.
- Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
- Vascular Medicine Department, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris-Centre Université Paris Cité (APHP-CUP), Paris, France.
- IRCCS Humanitas Research Hospital, Center for Thrombosis and Hemorrhagic Diseases.
- Internal Medicine Residency Program, School of Medicine, University of Insubria, Varese and Como, Italy, Varese.
- Department of Internal Medicine, Radboud university medical center, Nijmegen, Netherlands.
- Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany.
Abstract
BACKGROUND
There are limited data on functional and patient-reported outcomes after acute upper-extremity deep vein thrombosis (UEDVT) caused by compression syndromes.
OBJECTIVES
This study examined patient-reported functional impairment, quality of life, and treatment satisfaction after UEDVT.
METHODS
We did a retrospective multicenter cohort study of patients with confirmed UEDVT due to compression syndromes not related to central lines. Patients were included at 5 centers in 4 countries and completed a standardized patient-reported outcome survey. The primary outcome was upper-limb function measured via the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score (range, 0-100; higher scores indicate worse function) during follow-up. Quality of life was assessed using a Visual Analogue Scale. Additional outcomes included persistent symptoms, treatment satisfaction, mental health impact, and perception of unmet needs.
RESULTS
We included 82 patients (median age, 38 years; Q1-Q3, 26-48 years); 44% were women. All patients received anticoagulation, and 66% underwent catheter-directed therapy. First-rib resection was performed in 24% of patients. After a median follow-up of 16 months, 63% reported ≥1 persistent symptom, most commonly swelling (30%) and heaviness (29%). The median QuickDASH score was 8 (Q1-Q3, 2-20), indicating mild overall disability. QuickDASH correlated negatively with quality of life (Spearman ρ = -0.82; P < .001) and across QuickDASH items and countries. Symptom persistence emerged as the main predictor of residual functional impairment. Patient-reported priorities included maintaining adequate arm function (78%) and avoiding recurrent UEDVT (73%).
CONCLUSION
UEDVT can have lasting functional and psychosocial effects. Patient-reported outcomes reveal a burden that is not captured by traditional clinical metrics and should be integrated into routine care as well in the setting of interventional trials.
MeSH
Quality Of Life, Upper Extremity Deep Vein Thrombosis, Retrospective Studies, Outcome Assessment, Health Care, Patient Reported Outcome Measures, Postthrombotic Syndrome, Therapeutics, Venous Thromboembolism, Thrombosis, Veins