Journal Article Ahead of print
PubMed: 41718456 DOI: 10.1177/13524585261417120
Accelerated metabolomic aging and its association with social determinants of health in multiple sclerosis.
Mult Scler
Authors: Fatemeh Siavoshi, Rezvan Noroozi, Gina Chang, Vinicius A Schoeps, Matthew D Smith, Farren Bs Briggs, Jennifer S Graves, Emmanuelle Waubant, Ellen M Mowry, Peter A Calabresi, Pavan Bhargava, Kathryn C Fitzgerald
Affiliations
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- Department of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
- Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
- Division of Epidemiology, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
- Department of Neurosciences, University of California, San Diego, San Diego, CA, USA.
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Abstract
OBJECTIVES
Biological age may better capture differences in disease course among people with multiple sclerosis (PwMS) of identical chronological age. We investigated biological age acceleration through metabolomic age (mAge) in PwMS and its association with social determinants of health (SDoH) measured by area deprivation index (ADI).
METHODS
mAge was calculated for two cohorts: 323 PwMS and 66 healthy controls (HCs); 101 HCs and 71 DMT-naïve PwMS, using an aging clock derived from 11,977 healthy adults. mAge acceleration, the difference between mAge and chronological age, was compared between groups using generalized linear and mixed-effects models, and its association with ADI was assessed via linear regression.
RESULTS
Estimated mAge showed a modest correlation with chronological age (R 2≈0.20-0.25). Cross-sectionally, PwMS had higher age acceleration than HCs: 9.77 years in adult PwMS (95% CI: 6.57-12.97, p = 5.3e-09), and 4.90 years in adult DMT-naïve PwMS (95% CI: 0.85-9.01, p = 0.02). Longitudinally, PwMS aged 1.19 mAge years per chronological year (95% CI: 0.18-2.20; p = 0.02), faster than HCs. In PwMS, a 10-percentile increase in ADI was associated with a 0.63-year (95% CI: 0.10-1.18; p = 0.02) increase in age acceleration.
DISCUSSION
We demonstrated accelerated mAge in PwMS and its association with social disadvantage.
MeSH
Sclerosis, Multiple Sclerosis, Aging, Metabolomics