Journal Article Ahead of print
PubMed: 41720740 DOI: 10.1016/j.tem.2026.01.002
Microbial metabolites: messengers in the gut-X axis.
Trends Endocrinol Metab
Authors: Min Fu, Yusha Zhao, Dingjiacheng Jia
Affiliations
- Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang Province 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
- Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province 310058, China; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310058, China.
Abstract
Microbes can extensively regulate the physiological or pathological processes of host organs by secreting metabolites. Recently, Zhang et al. demonstrated that ectopic Catenibacterium mitsuokai could secrete quinolinic acid, activating the TIE2/PI3K/AKT pathway to drive hepatocellular carcinoma. These findings offer new insights into the microbial metabolite-target organ axis.
MeSH
Carcinoma, Hepatocellular, Metabolic Diseases, Quinolinic Acid, Hormones, Endocrine Glands, Gastrointestinal Microbiome, Endocrine System Diseases