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Publications

Journal Article Review Epublish

PubMed: 41799794 DOI: 10.3389/fdmed.2026.1701357

Periodontal disease and neuroinflammation in multiple sclerosis: a systematic review of current evidence.

Front Dent Med 7:1701357

Authors: Srijanani Santhanakrishnan, Karunanidhi Kannappan, Chandrasekaran Krithika, Chitathoor Sridhar, Jaideep Mahendra

Affiliations

  • Department of Research, Meenakshi Academy of Higher Education and Research, Chennai, India.
  • Oral Medicine and Radiology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.
  • Internal Medicine, Meenakshi Academy of Higher Education and Research, Chennai, India.
  • Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research, Chennai, India.

Abstract

BACKGROUND

Multiple Sclerosis (MS) is a chronic, immune-mediated neurological disorder characterized by demyelination and neurodegeneration. Emerging evidence suggests a link between MS and Periodontal Diseases (PD) through shared immune-inflammatory pathways. This review assesses the association between periodontal diseases and multiple sclerosis, focusing on immune-inflammatory interactions and clinical correlations. Despite emerging evidence, the strength of association remains unclear due to methodological heterogeneity.

AIM

To review and evaluate the literature on the epidemiological association between PD and MS in adults.

MATERIALS AND METHODS

A systematic search was conducted in PubMed, Scopus, and Cochrane. Studies with full text articles that are available in English, without time restrictions, that assessed periodontitis, oral microbiome, and salivary biomarkers in relation to MS were included. Observational studies evaluating clinical, microbiological, or immunological associations were selected. Data extraction covered periodontal parameters, salivary biomarkers, periodontal pathogens and disease severity. The risk of bias was evaluated using Newcastle-Ottawa Scale.

RESULTS

The findings indicated that patients with MS had poorer periodontal health, when compared to healthy controls. Dysbiosis in the oral microbiome was observed, with a higher abundance of periodontal pathogens. Patients with MS exhibited elevated neutrophil-lymphocyte ratios and total oxidative stress, indicating a potential link between systemic inflammation and periodontal dysbiosis. While some studies established positive association between PD and MS, others highlighted the need for further investigation due to inconsistent findings in periodontal parameters between MS patients and controls.

CONCLUSION

Despite methodological heterogeneity, the available limited evidence indicates the association between periodontitis and MS. This highlights the need for standardized periodontal assessments in research involving MS and suggests that periodontal care may hold potential as an adjunct in management of MS.

MeSH

Sclerosis, Multiple Sclerosis, Biomarkers, Periodontal Diseases, Periodontitis, Oral Microbiome