Journal Article Ahead of print
PubMed: 41871679 DOI: 10.1016/j.ahj.2026.107429
Enhancing Invasive Coronary Function Testing: Multivessel Assessment of Coronary Microvascular Dysfunction in Patients with Angina and No Obstructive Coronary Artery Disease (ANOCA).
Am Heart J
Authors: Andreas Tzoumas, Danielle N Tapp, Namrita Ashokprabu, Christian W Schmidt, Sukhleen Kaur, Jane Carnesi, Claire Hanycz, Evan Lahkia, Jacob T Davis, Kamryn Wilson, Audrey Baker, Anibelky Almanzar, Jenny Zhang, Elnaz Mahbub, Somesh Rai, Ayushi Mohan, Odayme Quesada, Timothy D Henry
Affiliations
- Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, OH; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH; Division of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, OH.
- Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, OH; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH.
- Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, OH; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH; Division of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, OH.
Abstract
Invasive coronary function testing (ICFT) is the gold standard for diagnosing coronary microvascular dysfunction (CMD) and is predominantly performed in the left anterior descending coronary artery (LAD). We analyzed a prospective registry of 231 patients with angina and no obstructive coronary artery disease (ANOCA) who underwent consecutive ICFT using the Doppler method in both the proximal LAD and the left circumflex (LCx) arteries for assessment of coronary flow reserve (CFR). ICFT with multivessel CFR assessment that included the LCx in addition to the LAD identified an additional 10% of patients with CMD (CFR<2.5) that would have been missed by LAD assessment only.
MeSH
Research Design, Coronary Artery Disease, Arteries, Cardiology, Blood Circulation